膀胱内灌注福尔马林治疗宫颈癌放疗后出血性膀胱炎

Intravesical formalin for hemorrhagic cystitis following irradiation of cancer of the cervix.

作者信息

Dewan A K, Mohan G M, Ravi R

机构信息

Department of Genitourinary Surgery, Cancer Institute (WIA), Adyar, Madras, India.

出版信息

Int J Gynaecol Obstet. 1993 Aug;42(2):131-5. doi: 10.1016/0020-7292(93)90626-8.

DOI:10.1016/0020-7292(93)90626-8

PMID:7901061

Abstract

OBJECTIVE

To determine the effectiveness of intravesical formalin instillation in hemorrhagic cystitis following irradiation of cancer of the cervix.

METHOD

Records were reviewed for 35 patients with hemorrhagic radiation cystitis who underwent treatment with 1% (n = 22), 2% (n = 10), and 4% formalin (n = 4), using Fair's technique.

RESULT

Complete response was seen in 31 patients (89%) and partial response in 3 patients (8%) after a single instillation. Minor complications were seen in 19 patients (54%). Major complications occurred in 11 patients (31%), with 5 cases requiring subsequent urinary diversion. One patient died of persistent bleeding and probable formalin toxicity. Hematuria recurred in 7 patients achieving complete response at a mean period of 8 months after treatment. A 1% solution was as effective in controlling hematuria as higher concentrations and was associated with significantly less morbidity.

CONCLUSION

Intravesical instillation of 1% formalin is an effective treatment for intractable hematuria secondary to radiation cystitis.

摘要

目的

确定膀胱内灌注福尔马林治疗宫颈癌放疗后出血性膀胱炎的有效性。

方法

回顾性分析35例接受福尔马林膀胱灌注治疗的放射性出血性膀胱炎患者的记录，其中1%福尔马林组（n = 22）、2%福尔马林组（n = 10）和4%福尔马林组（n = 4），采用Fair技术。

结果

单次灌注后，31例患者（89%）完全缓解，3例患者（8%）部分缓解。19例患者（54%）出现轻微并发症。11例患者（31%）出现严重并发症，其中5例需要随后进行尿流改道。1例患者死于持续性出血及可能的福尔马林毒性。7例完全缓解的患者在治疗后平均8个月出现血尿复发。1%福尔马林溶液在控制血尿方面与高浓度溶液效果相同，且发病率显著较低。