Donahue L A, Frank I N
Department of Urology, University of Rochester School of Medicine, New York.
J Urol. 1989 Apr;141(4):809-12. doi: 10.1016/s0022-5347(17)41016-0.
In an extensive search of the literature 235 cases of intractable hemorrhagic cystitis treated with intravesical formalin were identified. Effectiveness of therapy, rate of recurrence of hematuria, morbidity and mortality were analyzed with respect to concentration of formalin and to the etiology of hematuria. Increasing concentrations of formalin slightly improved effectiveness of therapy and reduced the rate of recurrence of hematuria. However, this often resulted in an increase in morbidity. When patients were categorized according to the etiology of intractable hematuria it was noted that lower concentrations of formalin were effective in controlling hematuria caused by either cyclophosphamide cystitis or unresectable carcinoma of the bladder. In contrast, higher formalin concentrations were required to control bleeding due to radiation cystitis.
在对文献进行广泛检索后，确定了235例采用膀胱内灌注福尔马林治疗的顽固性出血性膀胱炎病例。针对福尔马林浓度和血尿病因，分析了治疗效果、血尿复发率、发病率和死亡率。福尔马林浓度的增加在一定程度上提高了治疗效果并降低了血尿复发率。然而，这往往会导致发病率上升。当根据顽固性血尿的病因对患者进行分类时，发现较低浓度的福尔马林对控制环磷酰胺性膀胱炎或不可切除的膀胱癌引起的血尿有效。相比之下，控制放射性膀胱炎引起的出血则需要更高浓度的福尔马林。
