Schmitz F J, Schulz M M, Siripitayananon J, Hossain M B, van der Helm D
Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019-0370.
J Nat Prod. 1993 Aug;56(8):1339-49. doi: 10.1021/np50098a018.
Seven new briariane diterpene lactones were isolated from the gorgonian Solenopodium excavatum collected in New Guinea. One structure (4) was determined by X-ray diffraction and the remainder were elucidated by spectroscopic analysis. Six of the new briareolides, 4-9, exist in a conformation that is quite uncommon for representatives of this fairly large family of compounds, namely one in which the bonds joining the 10-membered ring to the 6-membered ring are nearly diaxially oriented. Conformational energy calculations are discussed as are the structural features that are responsible for the uncommon conformation. Mild cytotoxic activity was confirmed for 4.
从采集于新几内亚的柳珊瑚Solenopodium excavatum中分离出七种新的海扇二萜内酯。通过X射线衍射确定了一种结构（4），其余结构通过光谱分析得以阐明。六种新的海扇内酯，即4 - 9，其构象在这个相当大的化合物家族的代表中相当罕见，也就是说，连接十元环和六元环的键几乎是二轴向排列的。文中讨论了构象能量计算以及导致这种罕见构象的结构特征。已证实化合物4具有轻微的细胞毒性活性。
