[Clinical investigation by transcranial Doppler sonography of the effect of norepinephrine on cerebral arterial blood velocity of normotensive males].

Transcranial Doppler (TCD) sonography is a new, non-invasive method for evaluation of the hemodynamics of cerebral circulation. Using a 2-MHz probe, the intracranial middle, posterior, vertebral and basilar arteries can be isolated easily to obtain parameters of systolic, diastolic, mean velocities and pulsatility index (PI). Changes of blood velocities and PI can assist evaluation of the condition of intracranial arterial spasm, dilatation and cerebral vascular resistance. The purpose of this study is to evaluate the hemodynamic effect of norepinephrine (NE) on cerebral circulation. Eighteen normotensive male healthy volunteers (mean age 42 years) were studied with TCD before and during NE infusion (13-16 micrograms/min). Results showed that systolic, diastolic and mean arterial pressure were increased significantly during NE infusion. Blood velocities of middle, posterior, vertebral and basilar arteries also increased markedly. Increased cerebral vascular resistance with elevation of PI was also noted in all of the persons studied. These findings provide evidence that NE infusion induces intracerebral vasospasm.