Snellman E, Aromaa A, Jansén C T, Lauharanta J, Reunanen A, Jyrkinen-Pakkasvirta T, Luoma J, Waal J
Social Insurance Institution, Helsinki, Finland.
Acta Derm Venereol. 1993 Oct;73(5):388-92. doi: 10.2340/0001555573388392.
The long-term effects of psoriasis heliotherapy were studied in a randomized cross-over trial with a 2-year follow-up. We allocated 95 patients randomly to receive a 4-week heliotherapy course, either at the onset or in the middle of the follow-up period. After a highly significant immediate alleviation of psoriasis about 50% of the patients still had a reduction of psoriasis 6 months later and about 25% one year later. A favourable carry-over treatment effect was still observed during the second follow-up year. Taking advantage of the cross-over design, the effect of heliotherapy was calculated to be statistically significant during the first follow-up year, and the apparent long-term alleviation of psoriasis after the heliotherapy was reflected in a significant period effect. The alleviation of psoriasis was accompanied by a significant decrease in the use of antipsoriatic treatments.
在一项为期2年随访的随机交叉试验中，对银屑病日光疗法的长期效果进行了研究。我们将95名患者随机分配，使其在随访期开始时或中期接受为期4周的日光疗法疗程。在银屑病立即得到高度显著缓解后，约50%的患者在6个月后银屑病仍有减轻，约25%的患者在1年后仍有减轻。在第二次随访年期间仍观察到有利的延续治疗效果。利用交叉设计，计算得出日光疗法的效果在第一次随访年期间具有统计学意义，日光疗法后银屑病明显的长期缓解反映在显著的时期效应上。银屑病的减轻伴随着抗银屑病治疗使用的显著减少。
