Chaĭdo M A, Idova G V, Devoĭno L V
Biull Eksp Biol Med. 1993 Sep;116(9):291-2.
The modulating effect of the kappa-opiate agonist, rimorphin, on the immune response was studied. This opioid in all the doses tested (1, 10 and 100 mkg/kg) was found to cause inhibition of the immune reaction as compared to the control CBA mice which received saline only. The dissection of the pituitary stalk prevented the inhibitory effect of rimorphin on the immunity. The opioid-induced immunosuppression was shown to be due to interaction with the serotoninergic system since it had no effect after preliminary blockade of S-2 serotonin postsynaptic receptors with cyproheptadine.
研究了κ-阿片受体激动剂瑞莫啡对免疫反应的调节作用。与仅接受生理盐水的对照CBA小鼠相比，发现该阿片类药物在所有测试剂量（1、10和100微克/千克）下均会导致免疫反应受到抑制。切断垂体柄可防止瑞莫啡对免疫的抑制作用。阿片类药物诱导的免疫抑制被证明是由于与5-羟色胺能系统相互作用所致，因为在用赛庚啶对S-2 5-羟色胺突触后受体进行初步阻断后，它没有效果。
