[Role of the pituitary in modulating the effect of the dopaminergic and serotoninergic systems on the immune response].

Dissection of the pituitary stalk prevented the changes of the immune response caused with drugs influencing the activity of dopaminergic and serotoninergic systems. Stimulating effect of the dopamine receptor agonist--apomorphine, and inhibitory effect of blocking agent for these receptors--haloperidol on the immune response were not manifest in animals after lesion of the hypothalamo--pituitary stalk. The inhibitory action of serotoninergic system on the immunity (administration of serotonin and its precursor--5-hydroxytryptophan) was also prevented by interrupting the link between the hypothalamus and the hypophysis. The data obtained suggest central action of dopaminergic and serotoninergic systems on the immunity and indicate the important role of hypophysis in neuroimmunomodulation.