Al'perina E L, Idova G V, Devoĭno L V
Fiziol Zh SSSR Im I M Sechenova. 1985 Nov;71(11):1428-32.
Dissection of the pituitary stalk prevented the changes of the immune response caused with drugs influencing the activity of dopaminergic and serotoninergic systems. Stimulating effect of the dopamine receptor agonist--apomorphine, and inhibitory effect of blocking agent for these receptors--haloperidol on the immune response were not manifest in animals after lesion of the hypothalamo--pituitary stalk. The inhibitory action of serotoninergic system on the immunity (administration of serotonin and its precursor--5-hydroxytryptophan) was also prevented by interrupting the link between the hypothalamus and the hypophysis. The data obtained suggest central action of dopaminergic and serotoninergic systems on the immunity and indicate the important role of hypophysis in neuroimmunomodulation.
垂体柄离断可防止因影响多巴胺能和5-羟色胺能系统活性的药物所引起的免疫反应变化。多巴胺受体激动剂——阿扑吗啡的刺激作用以及这些受体阻断剂——氟哌啶醇对免疫反应的抑制作用，在下丘脑-垂体柄损伤后的动物中未表现出来。5-羟色胺能系统对免疫的抑制作用（给予5-羟色胺及其前体——5-羟色氨酸）也因下丘脑与垂体之间联系的中断而受到阻止。所获得的数据提示多巴胺能和5-羟色胺能系统对免疫有中枢作用，并表明垂体在神经免疫调节中起重要作用。
