[Participation of the hypophysis in immunomodulation during interaction with monoaminergic systems].

The participation of the pituitary gland in the actualization of dopamine-dependent immune response after removal of adrenals and an increase in the serotonin content, was studied in the CBA mice. A lesion of the pituitary stalk prevented the activation of immune response usually observed in adrenalectomized animals treated with serotonin. The data obtained suggest that exclusion of the serotoninergic immunomodulating pathways out of the CNS causes the predominance of dopaminergic system. Activating action of the latter on the immunity is actualized via the hypophysis and subsequently maintained by central mechanisms.