Kent S J, Stent G, Sonza S, Hunter S D, Crowe S M
AIDS Pathogenesis Research Unit, Macfarlane Burnet Centre for Medical Research, Fairfield, Australia.
Clin Exp Immunol. 1994 Mar;95(3):450-4. doi: 10.1111/j.1365-2249.1994.tb07017.x.
Fc receptor (FcR) and complement receptor (CR) expression on HIV-infected monocyte-derived macrophages may be an important determinant of immune function. We studied the effects of HIV-1 infection of macrophages in vitro on FcR and CR expression. Macrophages were infected with HIV-1DV 7 days following isolation, and the expression of Fc gamma RI-III and CR3 were measured at intervals thereafter by flow cytometry. We found a reduction in receptor expression with the percentage of cells expressing FcRI 14 days post infection declining from 77% to 13%, FcRII fell from 96% to 85%, FcRIII from 45% to 9%, and CR3 from 91% to 67% 14 days following infection. As these receptors are important for macrophage function, their down-modulation may contribute to the pathogenesis of HIV-related disease.
在感染HIV的单核细胞衍生巨噬细胞上，Fc受体（FcR）和补体受体（CR）的表达可能是免疫功能的一个重要决定因素。我们研究了体外HIV-1感染巨噬细胞对FcR和CR表达的影响。巨噬细胞在分离7天后用HIV-1DV感染，此后每隔一段时间通过流式细胞术测量FcγRI-III和CR3的表达。我们发现感染后14天，受体表达降低，表达FcRI的细胞百分比从77%降至13%，FcRII从96%降至85%，FcRIII从45%降至9%，CR3从91%降至67%。由于这些受体对巨噬细胞功能很重要，它们的下调可能有助于HIV相关疾病的发病机制。
