Pinching A J, McManus T J, Jeffries D J, Moshtael O, Donaghy M, Parkin J M, Munday P E, Harris J R
Lancet. 1983 Jul 16;2(8342):126-30. doi: 10.1016/s0140-6736(83)90115-0.
97 symptom-free homosexuals were studied clinically, serologically, and with in-vivo and in-vitro tests of cellular immune function in the context of the acquired immunodeficiency syndrome (AIDS). A high proportion of these men showed abnormalities: lymphopenia (33%), decreased T-helper/T-suppressor (Th/Ts) cell ratios (43%), both these abnormalities (12%), decreased total T-helper cells (15%), monocyte chemotactic (10%) and phagocytic (27%) defects, anergy to three recall antigens (32%), and anergy to purified protein derivative despite BCG inoculation (55%). The lymphocyte abnormalities and anergy characteristic of AIDS were seen in 5%. No clear clinical or serological associations were seen for the AIDS-like defects. Trends of association were seen between higher lymphocyte counts, lower Th/Ts ratios, more T-suppressor cells and serological evidence of previous virus infection. The combination of lymphocyte abnormalities and anergy observed in these symptom-free homosexuals may represent a latent phase of AIDS.
在获得性免疫缺陷综合征（艾滋病）的背景下，对97名无症状同性恋者进行了临床、血清学以及细胞免疫功能的体内和体外测试。这些男性中有很大比例表现出异常：淋巴细胞减少（33%）、辅助性T细胞/抑制性T细胞（Th/Ts）比例降低（43%）、这两种异常同时出现（12%）、总辅助性T细胞减少（15%）、单核细胞趋化（10%）和吞噬（27%）缺陷、对三种回忆抗原无反应（32%）以及尽管接种了卡介苗但对纯化蛋白衍生物无反应（55%）。5%的人出现了艾滋病特有的淋巴细胞异常和无反应性。未发现类似艾滋病的缺陷与明确的临床或血清学关联。在较高的淋巴细胞计数、较低的Th/Ts比例、较多的抑制性T细胞与既往病毒感染的血清学证据之间观察到了关联趋势。在这些无症状同性恋者中观察到的淋巴细胞异常和无反应性组合可能代表了艾滋病的潜伏期。
