Mann G V
Lancet. 1994 May 21;343(8908):1268-71. doi: 10.1016/s0140-6736(94)92157-1.
The epidemic of coronary heart disease in the western world followed the introduction of partially hydrogenated fats in food. Exposure to trans fatty acids (TFA) in those foods can explain the observed sex and age differences in serum cholesterol concentrations and coronary heart disease (CHD), the cholesterolaemic response to pregnancy, and national differences in rates of CHD. There is evidence that TFA can be innocuously used for muscular work. I propose that the TFA in partially hydrogenated fats impair lipoprotein receptors during energy surfeit, leading to hypercholesterolaemia, atherogenesis, obesity, and insulin resistance. A series of feasible experiments is proposed to examine this hypothesis.
西方世界冠心病的流行是在食品中引入部分氢化脂肪之后出现的。食用这些食物时接触反式脂肪酸（TFA）可以解释观察到的血清胆固醇浓度和冠心病（CHD）方面的性别和年龄差异、妊娠时的胆固醇血症反应以及冠心病发病率的国家差异。有证据表明，反式脂肪酸可无害地用于肌肉活动。我提出，在能量过剩时，部分氢化脂肪中的反式脂肪酸会损害脂蛋白受体，导致高胆固醇血症、动脉粥样硬化、肥胖和胰岛素抵抗。本文提出了一系列可行的实验来检验这一假设。
