大肠杆菌重组缺陷型突变体在与萘啶酸孵育期间的存活情况。
Survival of recombination-deficient mutants of Escherichia coli during incubation with nalidixic acid.
作者信息
McDaniel L S, Rogers L H, Hill W E
出版信息
J Bacteriol. 1978 Jun;134(3):1195-8. doi: 10.1128/jb.134.3.1195-1198.1978.
Abstract
The ability of several Escherichia coli strains deficient in recombination (rec) to survive in the presence of nalidixic acid was determined. Genetic blocks of the RecBC or the RecF pathways resulted in increased sensitivity to nalidixic acid when compared with the wild-type strain. Mutants lacking functional recA, recL, or recB recC recF genes showed the most rapid decrease in colony-forming ability when incubated with nalidixic acid. However, the uvrB gene also plays a role in maintaining cell viability.
摘要
测定了几种重组缺陷型（rec）大肠杆菌菌株在萘啶酸存在下的存活能力。与野生型菌株相比，RecBC或RecF途径的遗传阻断导致对萘啶酸的敏感性增加。缺乏功能性recA、recL或recB recC recF基因的突变体在与萘啶酸一起孵育时，菌落形成能力下降最快。然而，uvrB基因在维持细胞活力方面也起作用。
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