Srivastava S C
Industrial Toxicology Research Centre, Lucknow, India.
Int J Parasitol. 1994 Apr;24(2):249-51. doi: 10.1016/0020-7519(94)90032-9.
Infection of golden hamsters with Ancylostoma ceylanicum caused significant decrease in body weight, liver weight and the protein content of liver plasma membrane. Significant inhibition of liver plasma membrane enzymes activities-5'Nucleotidase, gamma-glutamyl transpeptidase, NADHK3Fe (CN)6 reductase, Na+/K(+)-ATPase, CA(2+)-ATPase and Mg(2+)-ATPase was observed in infected animals compared to corresponding controls. Sialic acid content and phospholipid/cholesterol ratio in liver plasma membrane of the infected group were significantly reduced. The study suggests that changes in both the structural and functional organization of membrane may be a biochemical basis of the hepatotoxic effects.
用锡兰钩口线虫感染金黄仓鼠会导致体重、肝脏重量以及肝细胞膜蛋白质含量显著下降。与相应对照组相比，在受感染动物中观察到肝细胞膜酶活性——5'核苷酸酶、γ-谷氨酰转肽酶、NADHK3Fe(CN)6还原酶、Na+/K(+)-ATP酶、Ca(2+)-ATP酶和Mg(2+)-ATP酶受到显著抑制。感染组肝细胞膜中的唾液酸含量和磷脂/胆固醇比率显著降低。该研究表明，膜的结构和功能组织的变化可能是肝毒性作用的生化基础。
