Trzepacz P T
University of Pittsburgh School of Medicine, Consultation-Liaison Program, PA 15213.
Psychosomatics. 1994 Jul-Aug;35(4):374-91. doi: 10.1016/S0033-3182(94)71759-X.
Delirium symptoms suggest dysfunction of multiple brain regions. However, little is known about delirium's underlying neuropathogenesis. This article addresses the need for research on neuroanatomic and neuropathophysiologic underpinnings of delirium, analogous to that of schizophrenia and affective disorders. Electrophysiologic tests, structural and functional brain imaging, and neurotransmitter studies in delirium are critically reviewed. The importance of both cerebral cortical and subcortical areas is noted, with emphasis on frontal, right-hemisphere, and subcortical regions, including caudate and anteromedial thalamus. Each symptom of delirium can be viewed from a neuroanatomic and neurochemical perspective. Recommendations for research are made throughout the article.
谵妄症状提示多个脑区功能障碍。然而，对于谵妄潜在的神经发病机制知之甚少。本文论述了开展谵妄神经解剖学和神经病理生理学基础研究的必要性，此类研究类似于针对精神分裂症和情感障碍所开展的研究。本文对谵妄的电生理测试、脑结构和功能成像以及神经递质研究进行了批判性综述。文中指出了大脑皮层和皮层下区域的重要性，重点强调了额叶、右半球以及皮层下区域，包括尾状核和丘脑前内侧。谵妄的每种症状都可以从神经解剖学和神经化学角度进行审视。本文通篇都给出了研究建议。
