Seamans J K, Phillips A G
Department of Psychology, University of British Columbia, Vancouver, Canada.
Behav Neurosci. 1994 Jun;108(3):456-68. doi: 10.1037//0735-7044.108.3.456.
Reversible lidocaine-induced lesions of the nucleus accumbens (N.Acc.) impaired performance on the spatial win-shift, but not on the cued win-stay, radial arm maze task. Pretraining lesions on the former task did not affect foraging for 4 pellets during either the training or test phases. In contrast, lesions given prior to the test phase significantly disrupted retrieval of 4 pellets on the 8-arm maze. Comparable deficits also were observed in rats trained to forage for 4 pellets on an 8-arm maze without prior win-shift experience. State-dependent drug effects were ruled out by replicating the disruptive effects of lidocaine infusions into the N.Acc. on spatial win-shift performance in rats receiving this treatment prior to both training and test phases. These results suggest that the N.Acc. may interact with the hippocampus to guide foraging behavior requiring memory of previous spatial locations on a maze.
伏隔核（N.Acc.）中利多卡因诱导的可逆性损伤损害了空间赢-转换任务的表现，但不影响线索赢-停留放射状臂迷宫任务的表现。在前一项任务上的预训练损伤在训练或测试阶段均不影响对4颗食丸的觅食。相比之下，在测试阶段之前进行的损伤显著破坏了在8臂迷宫上对4颗食丸的找回。在没有先前赢-转换经验的情况下接受训练在8臂迷宫上觅食4颗食丸的大鼠中也观察到了类似的缺陷。通过在训练和测试阶段之前接受这种治疗的大鼠中复制向伏隔核注入利多卡因对空间赢-转换表现的破坏作用，排除了状态依赖性药物效应。这些结果表明，伏隔核可能与海马体相互作用，以指导需要记忆迷宫中先前空间位置的觅食行为。
