Gal G, Joel D, Gusak O, Feldon J, Weiner I
Department of Psychology, Tel Aviv University, Israel.
Behav Neurosci. 1997 Feb;111(1):92-103. doi: 10.1037//0735-7044.111.1.92.
The effects of bilateral electrolytic lesions of the "shell" subterritory of the nucleus accumbens in the rat were examined on 2 tasks known to be sensitive to hippocampal damage. Experiment 1 tested the effects of shell lesion on delayed non-matching-to-sample (DNMS) task in a T-maze. The maze was rotated 180 degrees after the end of acquisition. Experiment 2 used a 4-arm baited, 4-arm unbaited, 8-arm radial-maze task and its reversal. Shell lesion led to impaired acquisition of DNMS in a T-maze and of 4-arm baited, 4-arm unbaited, 8-arm radial maze tasks, suggestive of mnemonic deficits. Following analysis of animals' choice pattern in both tasks, the deficit was interpreted as being largely due to an extensive use of response strategy. The results suggest that the inappropriate use of response strategy by shell animals was a result of their inability to switch from initial response strategy to a later, more appropriate, memory-dependent strategy.
研究了大鼠伏隔核“壳”亚区双侧电解损伤对两项已知对海马损伤敏感的任务的影响。实验1测试了壳损伤对T型迷宫中延迟非匹配样本（DNMS）任务的影响。在习得结束后，将迷宫旋转180度。实验2使用了一个四臂有饵、四臂无饵、八臂放射状迷宫任务及其反转任务。壳损伤导致在T型迷宫以及四臂有饵、四臂无饵、八臂放射状迷宫任务中的DNMS习得受损，提示存在记忆缺陷。在分析了两项任务中动物的选择模式后，该缺陷被解释为主要是由于广泛使用反应策略所致。结果表明，壳损伤动物对反应策略的不当使用是由于它们无法从初始反应策略转换为后来更合适的、依赖记忆的策略。
