Kiyosawa I, Aoki M, Imamura T, Shibata N, Naito J, Saito T R, Takahashi K W
Kissei Pharmaceutical Co., Ltd., Nagano, Japan.
Jikken Dobutsu. 1994 Jul;43(3):409-12. doi: 10.1538/expanim1978.43.3_409.
Changes in the visual organ with aging were investigated non-surgically in male WBN/Kob rats, in which spontaneous diabetic mellitus commonly occurs. Male Wistar/ST rats at the ages of 5, 9, 13, 17, 23, 27, 36, 45, 54, 67 and 80 weeks were examined for changes in the peri-orbital region, eyelid, lens, corpus vitreum and ocular fundus by macroscopic inspection and fundoscopy. The area around the eyelid was stained with reddish-brown excretions from the Harderian gland. This stain was frequently observed in rats of both strains aged 54 weeks or over, showing no difference in frequency between WBN/Kob rats and Wistar/ST rats. Lens opacity was observed in male WBN/Kob rats aged 67 weeks or over, and narrowing of the retinal artery and vein in those aged 36 weeks or over. The occurrence of lens opacity was consistent with that of visual dysfunction as determined by a test of the ability to differentiate light from dark using a Y-shaped apparatus (Kiyosawa et al., 1993).
在通常会自发发生糖尿病的雄性WBN/Kob大鼠中，采用非手术方法研究了视觉器官随衰老的变化。对5、9、13、17、23、27、36、45、54、67和80周龄的雄性Wistar/ST大鼠，通过肉眼检查和眼底镜检查，观察眶周区域、眼睑、晶状体、玻璃体和眼底的变化。眼睑周围区域被哈德氏腺的红棕色分泌物染色。在54周龄及以上的两种品系大鼠中均经常观察到这种染色，WBN/Kob大鼠和Wistar/ST大鼠在出现频率上没有差异。在67周龄及以上的雄性WBN/Kob大鼠中观察到晶状体混浊，在36周龄及以上的大鼠中观察到视网膜动静脉变窄。晶状体混浊的发生与使用Y形装置进行明暗辨别能力测试所确定的视觉功能障碍一致（Kiyosawa等人，1993年）。
