Kiyosawa I, Aoki M, Imamura T, Sibata N, Naito J, Saito T R, Takahashi K W
Kissei Pharmaceutical Co., Ltd., Nagano, Japan.
Jikken Dobutsu. 1993 Oct;42(4):647-51. doi: 10.1538/expanim1978.42.4_647.
Changes in visual function with increasing age were studied in male WBN/Kob rats, a new diabetic strain. In order to detect visual abnormalities in WBN/Kob rats, 5 WBN/Kob and 5 Wistar/ST (control) rats from each group were examined at 5, 9, 13, 17, 23, 27, 36, 45, 54, 67 and 80 weeks of age using dark and light distinction and open-field tests. The rates at which WBN/Kob rats selected the dark area were 85.0 to 100%, 58.8% and 52.6% at 5 to 54, 67 and 80 weeks of age, respectively, while those for Wistar/ST rats were 85.0 to 100% in each age group. Visual abnormality was obvious in WBN/Kob rats aged 67 and 80 weeks, compared with Wistar/ST rats (P < 0.05). There were no significant signs of visual abnormality in the open-field test. Detection of visual abnormality seems to be possible from 67 weeks of age.
在一种新的糖尿病品系雄性WBN/Kob大鼠中研究了视觉功能随年龄增长的变化。为了检测WBN/Kob大鼠的视觉异常，在5、9、13、17、23、27、36、45、54、67和80周龄时，使用明暗辨别和旷场试验对每组的5只WBN/Kob大鼠和5只Wistar/ST（对照）大鼠进行检查。WBN/Kob大鼠在5至54周龄、67周龄和80周龄时选择暗区的比例分别为85.0%至100%、58.8%和52.6%，而Wistar/ST大鼠在每个年龄组中的比例为85.0%至100%。与Wistar/ST大鼠相比，67周龄和80周龄的WBN/Kob大鼠视觉异常明显（P<0.05）。在旷场试验中没有明显的视觉异常迹象。似乎从67周龄开始就可以检测到视觉异常。
