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癌胚抗原（CEA）相关抗原在正常食管鳞状黏膜和鳞状细胞癌中的表达分类及定位

Classification and localisation of carcinoembryonic antigen (CEA) related antigen expression in normal oesophageal squamous mucosa and squamous carcinoma.

作者信息

Sanders D S, Wilson C A, Bryant F J, Hopkins J, Johnson G D, Milne D M, Kerr M A

机构信息

Department of Pathology, Medical School, University of Birmingham.

出版信息

Gut. 1994 Aug;35(8):1022-5. doi: 10.1136/gut.35.8.1022.

DOI:10.1136/gut.35.8.1022
PMID:7926898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1375047/
Abstract

Using a panel of carcinoembryonic antigen (CEA) related antibodies in normal oesophageal squamous mucosa CEA expression is present on suprabasal squames localised to the cell membrane. Immunoblotting shows that this positivity is predominantly due to a glycoprotein of around 180 kDa representing CEA itself. Positivity in squamous carcinomas is confined to cells in foci of squamous differentiation. A shift from membranous localisation to predominant cytoplasmic overexpression is shown between normal and malignant squames using confocal microscopy. The recognition of an adhesive role for CEA and a role in enhancing distant metastases in those tumours expressing CEA highlights the importance of recording CEA expression and changes in subcellular distribution between normal and malignant tissues; CEA expression in oesophageal squamous mucosa has not been well recognised previously and changes in expression may prove of great significance in the spread and dissemination of squamous carcinoma.

摘要

在正常食管鳞状黏膜中使用一组癌胚抗原（CEA）相关抗体，CEA表达存在于位于细胞膜的基底上层鳞状细胞中。免疫印迹显示，这种阳性主要归因于一种约180 kDa的糖蛋白，即CEA本身。鳞状细胞癌中的阳性仅限于鳞状分化灶中的细胞。使用共聚焦显微镜观察发现，正常和恶性鳞状细胞之间存在从膜定位到主要细胞质过表达的转变。认识到CEA的黏附作用以及在那些表达CEA的肿瘤中增强远处转移的作用，突出了记录CEA表达以及正常和恶性组织之间亚细胞分布变化的重要性；食管鳞状黏膜中的CEA表达以前未得到充分认识，表达变化可能在鳞状细胞癌的扩散和播散中具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c5a/1375047/024ddd97c399/gut00542-0022-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c5a/1375047/08f42ed49720/gut00542-0020-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c5a/1375047/d401e3fbf757/gut00542-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c5a/1375047/cf1047f778bc/gut00542-0021-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c5a/1375047/9fea3550b00b/gut00542-0021-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c5a/1375047/024ddd97c399/gut00542-0022-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c5a/1375047/08f42ed49720/gut00542-0020-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c5a/1375047/d401e3fbf757/gut00542-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c5a/1375047/cf1047f778bc/gut00542-0021-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c5a/1375047/9fea3550b00b/gut00542-0021-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c5a/1375047/024ddd97c399/gut00542-0022-a.jpg

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本文引用的文献

1
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J Pathol. 1993 Sep;171(1):21-6. doi: 10.1002/path.1711710106.
2
The prognostic value of CEA determinations in the plasma of patients with squamous cell cancer of the cervix.宫颈癌鳞状细胞癌患者血浆中癌胚抗原检测的预后价值。
Cancer. 1982 Jul 15;50(2):283-7. doi: 10.1002/1097-0142(19820715)50:2<283::aid-cncr2820500219>3.0.co;2-h.
3
Ultrastructural localization of carcinoembryonic antigen in normal intestine and colon cancer: abnormal distribution of CEA on the surfaces of colon cancer cells.
食管癌患者血清癌胚抗原、糖类抗原19-9及鳞状细胞癌抗原水平的临床意义
World J Surg. 2004 Jul;28(7):680-5. doi: 10.1007/s00268-004-6865-y. Epub 2004 Jun 4.
4
Lewis blood group and CEA related antigens; coexpressed cell-cell adhesion molecules with roles in the biological progression and dissemination of tumours.刘易斯血型和癌胚抗原相关抗原；共同表达的细胞间黏附分子，在肿瘤的生物学进展和扩散中发挥作用。
Mol Pathol. 1999 Aug;52(4):174-8. doi: 10.1136/mp.52.4.174.
癌胚抗原在正常肠组织和结肠癌中的超微结构定位：癌胚抗原在结肠癌细胞表面的异常分布。
Cancer. 1982 May 15;49(10):2077-90. doi: 10.1002/1097-0142(19820515)49:10<2077::aid-cncr2820491020>3.0.co;2-x.
4
Differences in the ultrastructural localization of carcinoembryonic antigen in human breast and in colon tumour cells.癌胚抗原在人乳腺癌和结肠肿瘤细胞中的超微结构定位差异。
Tumour Biol. 1984;5(5):233-42.
5
CEA positivity in sera and breast tumor tissues obtained from the same patients.
Pathol Res Pract. 1982;173(4):390-401. doi: 10.1016/S0344-0338(82)80006-X.
6
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7
Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: homophilic and heterophilic adhesion.在CHO细胞表面表达的非特异性交叉反应抗原（NCA）和癌胚抗原（CEA）的细胞黏附活性：同种亲和黏附和异种亲和黏附。
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