Setti-Carraro P, Ritchie J K, Wilkinson K H, Nicholls R J, Hawley P R
St Mark's Hospital, London.
Gut. 1994 Aug;35(8):1070-5. doi: 10.1136/gut.35.8.1070.
Between 1976 and 1985, 110 patients had restorative proctocolectomy or proctectomy for ulcerative colitis and 103 were followed up until death or February 1992. There was one postoperative and one late death related to surgery. The cumulative probability of pouch failure was 12% at five years: half of the failures occurred within one year. The commonest reasons were perianal/pelvic sepsis and probable Crohn's disease. The cumulative probability of readmission, excluding that for ileostomy closure, was 68% at five years. There were 152 operations carried out during readmissions. These included 44 laparotomies. Function was assessed in 80 patients at a mean of 99.3 months after ileostomy closure. For 66 patients with spontaneous evacuation, average minimum diurnal frequency was 3.8, maximum 4.9, with 35 evacuating at night. One patient experienced major continence problems, 30 had minor leaks, and 49 were completely continent. Postoperatively, five patients gave birth to nine babies, four had renal stones, two myasthenia gravis, and two severe anaemia: seven had pre or postoperative thyroid dysfunction.
1976年至1985年间，110例溃疡性结肠炎患者接受了保留直肠的结肠直肠切除术或直肠切除术，其中103例随访至死亡或1992年2月。术后有1例死亡，另有1例晚期死亡与手术相关。5年时储袋功能衰竭的累积概率为12%：一半的功能衰竭发生在1年内。最常见的原因是肛周/盆腔感染和可能的克罗恩病。5年时再次入院（不包括回肠造口关闭术）的累积概率为68%。再次入院期间共进行了152次手术，其中包括44次剖腹手术。在80例患者回肠造口关闭术后平均99.3个月时对其功能进行了评估。66例能够自主排便的患者，平均每日排便最少频率为3.8次，最多为4.9次，35例患者夜间排便。1例患者存在严重的控便问题，30例有轻微渗漏，49例完全控便。术后，5例患者生育了9名婴儿，4例患肾结石，2例患重症肌无力，2例患严重贫血：7例患者术前或术后存在甲状腺功能障碍。
