用诺卡氏菌组分治疗放射病：炎性细胞因子的可能作用

Treatment of radiation disease by Nocardia fraction: possible effect of inflammatory cytokines.

作者信息

Mandel L, Trebichavský I, Tlaskalová H, Sinkora J, Splíchal I, Barot-Ciorbaru R

机构信息

Institute of Microbiology, Academy of Sciences of Czech Republic, Prague.

出版信息

Int J Immunopharmacol. 1994 May-Jun;16(5-6):481-5. doi: 10.1016/0192-0561(94)90040-x.

DOI:10.1016/0192-0561(94)90040-x

PMID:7927997

Abstract

Nocardia delipidated cell mitogen (NDCM) derived from Nocardia opaca, given 2 h after whole-body gamma irradiation (2.5 Gy) to germ-free piglets in amounts of 1 mg/kg via a stomach tube, prevented the loss of B-cells in the spleen, intestinal mucosa, and mesenteric lymph nodes when recorded on day 8 after irradiation. NDCM and/or formolized Enterococcus faecalis strain (Ef) applied intraperitoneally also 2 h after irradiation increased the survival rate in mice irradiated with 8.3 Gy and 8.5 Gy doses. The number of nucleated bone marrow cells and the content of RNA in the spleen were significantly higher in rats given immunostimulators NDCM and Ef after irradiation with 5.0 Gy. The effect is presumed to be a consequence of stimulated production of inflammatory cytokines.

摘要

从不透明诺卡氏菌中提取的诺卡氏菌脱脂细胞促有丝分裂原（NDCM），在对无菌仔猪进行全身γ射线照射（2.5 Gy）2小时后，通过胃管以1 mg/kg的剂量给予，在照射后第8天记录时，可防止脾脏、肠黏膜和肠系膜淋巴结中B细胞的丢失。照射后2小时腹腔注射NDCM和/或甲醛化粪肠球菌菌株（Ef），也可提高接受8.3 Gy和8.5 Gy剂量照射的小鼠的存活率。在接受5.0 Gy照射的大鼠中，给予免疫刺激剂NDCM和Ef后，有核骨髓细胞数量和脾脏中RNA含量显著更高。据推测，这种作用是炎性细胞因子产生受刺激的结果。