胎儿弯曲菌菌血症持续存在与调理素抗体缺乏有关。
Persistence of Campylobacter fetus bacteremia associated with absence of opsonizing antibodies.
作者信息
Neuzil K M, Wang E, Haas D W, Blaser M J
机构信息
Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
出版信息
J Clin Microbiol. 1994 Jul;32(7):1718-20. doi: 10.1128/jcm.32.7.1718-1720.1994.
Abstract
Campylobacter fetus causes systemic infections in immunocompromised hosts. We describe a case in which C. fetus bacteremia apparently relapsed after 7 years in a patient with hypogammaglobulinemia and characterize the serum resistance of the patient's C. fetus strain and the inability of the patient's serum, with and without commercial intravenous immunoglobulin, to opsonize this and another C. fetus strain effectively. The probable presence of a sequestered site of infection in bone, the intrinsic serum resistance of the C. fetus strain, and the absence of specific antibody may account for the persistent infection in this patient. These studies suggest that intravenous immunoglobulin treatment is not useful in eradicating C. fetus bacteremia.
摘要
胎儿弯曲杆菌可在免疫功能低下的宿主中引起全身感染。我们描述了一例低丙种球蛋白血症患者，其胎儿弯曲杆菌菌血症在7年后明显复发，并对该患者的胎儿弯曲杆菌菌株的血清抗性以及该患者的血清（无论有无商业静脉注射免疫球蛋白）有效调理此菌株和另一胎儿弯曲杆菌菌株的能力进行了表征。骨骼中可能存在隐匿性感染部位、胎儿弯曲杆菌菌株固有的血清抗性以及缺乏特异性抗体可能是该患者持续感染的原因。这些研究表明，静脉注射免疫球蛋白治疗对根除胎儿弯曲杆菌菌血症无效。
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