Ubbink J B, Vermaak W J, van der Merwe A, Becker P J, Delport R, Potgieter H C
Department of Chemical Pathology, Faculty of Medicine, University of Pretoria, South Africa.
J Nutr. 1994 Oct;124(10):1927-33. doi: 10.1093/jn/124.10.1927.
We have previously shown that a modest vitamin supplement containing folic acid, vitamin B-12 and vitamin B-6 is effective in reducing elevated plasma homocysteine concentrations. The effect of supplementation of the individual vitamins on moderate hyperhomocysteinemia has now been investigated in a placebo-controlled study. One hundred men with hyperhomocysteinemia were randomly assigned to five groups and treated with a daily dose of placebo, folic acid (0.65 mg), vitamin B-12 (0.4 mg), vitamin B-6 (10 mg) or a combination of the three vitamins for 6 wk. Folic acid supplementation reduced plasma homocysteine concentrations by 41.7% (P < 0.001), whereas the daily vitamin B-12 supplement lowered homocysteine concentrations by 14.8% (P < 0.01). The daily pyridoxine dose did not reduce significantly plasma homocysteine concentrations. The combination of the three vitamins reduced circulating homocysteine concentrations by 49.8%, which was not significantly different (P = 0.48) from the reduction achieved by folate supplementation alone. Our results indicate that folate deficiency may be an important cause of hyperhomocysteinemia in the general population.
我们之前已经表明，一种含有叶酸、维生素B-12和维生素B-6的适度维生素补充剂能有效降低血浆同型半胱氨酸浓度升高的情况。现在，在一项安慰剂对照研究中，对补充单一维生素对中度高同型半胱氨酸血症的影响进行了调查。100名患有高同型半胱氨酸血症的男性被随机分为五组，分别每日服用安慰剂、叶酸（0.65毫克）、维生素B-12（0.4毫克）、维生素B-6（10毫克）或这三种维生素的组合，持续6周。补充叶酸使血浆同型半胱氨酸浓度降低了41.7%（P<0.001），而每日补充维生素B-12使同型半胱氨酸浓度降低了14.8%（P<0.01）。每日服用吡哆醇并未显著降低血浆同型半胱氨酸浓度。三种维生素的组合使循环中的同型半胱氨酸浓度降低了49.8%，与单独补充叶酸所达到的降低幅度相比，无显著差异（P = 0.48）。我们的结果表明，叶酸缺乏可能是普通人群中高同型半胱氨酸血症的一个重要原因。
