Ubbink J B, Vermaak W J, van der Merwe A, Becker P J
Department of Chemical Pathology, Faculty of Medicine, University of Pretoria, South Africa.
Am J Clin Nutr. 1993 Jan;57(1):47-53. doi: 10.1093/ajcn/57.1.47.
We measured the vitamin B-6, vitamin B-12, and folic acid nutritional status in a group of apparently healthy men (n = 44) with moderate hyperhomocysteinemia (plasma homocysteine concentration > 16.3 mumol/L). Compared with control subjects (n = 274) with normal plasma homocysteine (< or = 16.3 mumol/L) concentrations, significantly lower plasma concentrations of pyridoxal-5'-phosphate (P < 0.001), cobalamin (P < 0.001), and folic acid (P = 0.004) were demonstrated in hyperhomocysteinemic men. The prevalence of suboptimal vitamin B-6, B-12, and folate status in men with hyperhomocysteinemia was 25.0%, 56.8%, and 59.1%, respectively. In a placebo-controlled follow-up study, a daily vitamin supplement (10 mg pyridoxal, 1.0 mg folic acid, 0.4 mg cyanocobalamin) normalized elevated plasma homocysteine concentrations within 6 wk. Because hyperhomocysteinemia is implicated as a risk factor for premature occlusive vascular disease, appropriate vitamin therapy may be both efficient and cost-effective to control elevated plasma homocysteine concentrations.
我们检测了一组血浆同型半胱氨酸中度升高（血浆同型半胱氨酸浓度>16.3μmol/L）的貌似健康男性（n = 44）的维生素B-6、维生素B-12和叶酸营养状况。与血浆同型半胱氨酸浓度正常（≤16.3μmol/L）的对照组受试者（n = 274）相比，高同型半胱氨酸血症男性的血浆磷酸吡哆醛（P<0.001）、钴胺素（P<0.001）和叶酸（P = 0.004）浓度显著降低。高同型半胱氨酸血症男性中维生素B-6、B-12和叶酸状态欠佳的患病率分别为25.0%、56.8%和59.1%。在一项安慰剂对照的随访研究中，每日补充维生素（10mg磷酸吡哆醛、1.0mg叶酸、0.4mg氰钴胺）可在6周内使升高的血浆同型半胱氨酸浓度恢复正常。由于高同型半胱氨酸血症被认为是过早发生闭塞性血管疾病的危险因素，适当的维生素治疗对于控制升高的血浆同型半胱氨酸浓度可能既有效又具有成本效益。
