Franceschi S, Dal Maso L, Arniani S, Crosignani P, Vercelli M, Simonato L, Falcini F, Zanetti R, Barchielli A, Serraino D, Rezza G
Servizio di Epidemiologia, Centro di Riferimento Oncologico, Aviano (PN), Italy.
Br J Cancer. 1998 Oct;78(7):966-70. doi: 10.1038/bjc.1998.610.
Record linkage was carried out between the national Registry of AIDS and 13 Cancer Registries (CRs) covering, in 1991, about 15% of the Italian population. Observed and expected numbers of cancers and standardized incidence ratios (SIRs) were assessed in 6067 persons with AIDS, for a total of 25,759 person-years. Significantly increased SIRs were found for Hodgkin's disease [8.9, 95% confidence interval (CI) 4.4-16.0], in which seven of 11 cases were of mixed cellularity type; invasive carcinoma of the cervix uteri (15.5; 95% CI 4.0-40.1); and non-melanomatous skin cancer (3.0, 95% CI 1.3-5.9), in which five of eight cases were basal cell carcinoma. An excess was also seen for brain tumours, but this may be partly due to misdiagnosis of brain non-Hodgkin's lymphoma or other brain diseases occurring near the time of the AIDS diagnosis. The risk for all cancer types, after exclusion of Kaposi's sarcoma (KS) and non-Hodgkin's lymphoma (NHL), was approximately twice the general population risk. An increased SIR for Hodgkin's disease in persons with AIDS is thus confirmed, though it is many times smaller than that for NHL. An association with invasive carcinoma of the cervix is also shown at a population level. The excess of non-melanomatous skin cancer seems to be lower than in transplant recipients.
在国家艾滋病登记处与13个癌症登记处（CRs）之间进行了记录链接，这些登记处覆盖了1991年约15%的意大利人口。对6067名艾滋病患者进行了癌症的观察病例数和预期病例数以及标准化发病率（SIRs）的评估，总计25759人年。发现霍奇金病的SIRs显著升高[8.9，95%置信区间（CI）4.4 - 16.0]，其中11例中有7例为混合细胞型；子宫颈浸润癌（15.5；95%CI 4.0 - 40.1）；以及非黑素瘤皮肤癌（3.0，95%CI 1.3 - 5.9），其中8例中有5例为基底细胞癌。脑肿瘤也有超额情况，但这可能部分归因于艾滋病诊断时附近发生的脑非霍奇金淋巴瘤或其他脑部疾病的误诊。排除卡波西肉瘤（KS）和非霍奇金淋巴瘤（NHL）后，所有癌症类型的风险约为一般人群风险的两倍。因此，艾滋病患者中霍奇金病的SIR升高得到了证实，尽管其比NHL的SIR小很多倍。在人群层面也显示出与子宫颈浸润癌有关联。非黑素瘤皮肤癌的超额情况似乎低于移植受者。
