Tishler M, Golbrut B, Shoenfeld Y, Yaron M
Department of Rheumatology, Elias Sourasky Medical Center, Ichilov Hospital, Tel Aviv, Israel.
J Rheumatol. 1994 Jun;21(6):1040-2.
To determine whether anti-Ro antibodies are associated with gold induced side effects.
A retrospective chart review of 208 patients with rheumatoid arthritis (RA) and examination of sera for the presence of anti-Ro antibodies by enzyme linked immunosorbent assay.
Anti-Ro antibodies were detected in 44 (21%) of our patients with RA and their presence correlated with positive rheumatoid factor, antinuclear antibody, and secondary Sjögren's syndrome. Thirty-three out of 48 patients with gold induced side effects (69%) were anti-Ro positive in contrast to 11 patients (7.5%) with positive antibodies with no side effects (p < 0.001). Mucocutaneous reactions had the only significant correlation (p < 0.01) with the presence of anti-Ro antibodies.
Patients with RA with anti-Ro antibodies are prone to develop mucocutaneous side effects to gold salts.
确定抗Ro抗体是否与金制剂所致副作用相关。
对208例类风湿关节炎（RA）患者进行回顾性病历审查，并通过酶联免疫吸附测定法检测血清中抗Ro抗体的存在情况。
在我们的208例RA患者中，44例（21%）检测到抗Ro抗体，其存在与类风湿因子、抗核抗体及继发性干燥综合征呈正相关。48例出现金制剂所致副作用的患者中，33例（69%）抗Ro抗体呈阳性，而11例无副作用且抗体呈阳性的患者中，仅1例（7.5%）抗Ro抗体呈阳性（p<0.001）。皮肤黏膜反应与抗Ro抗体的存在仅具有显著相关性（p<0.01）。
患有抗Ro抗体的RA患者易于出现金盐所致的皮肤黏膜副作用。
