Schneeberger Emilce, Citera Gustavo, Heredia Monica, Maldonado Cocco José
Rheumatology, Instituto de Rehabilitación Psicofísica, Echeverria 955, Buenos Aires, Argentina.
Clin Rheumatol. 2008 Apr;27(4):517-9. doi: 10.1007/s10067-007-0812-x. Epub 2008 Jan 8.
The objective of our study was to determine the frequency of anti-Ro antibodies in patients with rheumatoid arthritis (RA), their clinical significance and possible serologic and genetic associations. Consecutive patients with RA (ACR '87) were studied. Other connective tissues diseases were excluded. Demographic characteristics, extra articular manifestations, and treatment were reviewed. Presence of leukopenia, thrombocytopenia, hypergammaglobulinemia, hypocomplementemia, and cryoglobulinemia were consigned. Rheumatoid factor (RF), antinuclear antibodies (ANAs), anti-Ro, and anti-La were determined by ELISA in all patients; and HLA-DR was determined by PCR and oligotyping. X-rays of the hands and feet were evaluated by Larsen's score. The study included 106 patients, 94 women and 12 men; mean age was 50.3 +/- 11.4 years, mean disease duration was 11.2 +/- 6.8 years. Main extra articular manifestations were subcutaneous nodules, xerophthalmia, and xerostomia; 75.5% of the patients were RF+. Anti-Ro antibodies were detected in 12.2% of the patients. When positive and negative anti-Ro patients were compared, no significant difference in any studied variable was observed. According to our results, anti-Ro antibodies lack clinical relevance in patients with RA.
我们研究的目的是确定类风湿关节炎（RA）患者中抗Ro抗体的频率、其临床意义以及可能的血清学和遗传学关联。对符合美国风湿病学会（ACR）1987年标准的连续RA患者进行了研究，排除了其他结缔组织病。回顾了患者的人口统计学特征、关节外表现和治疗情况。记录白细胞减少、血小板减少、高球蛋白血症、低补体血症和冷球蛋白血症的存在情况。所有患者均通过酶联免疫吸附测定（ELISA）检测类风湿因子（RF）、抗核抗体（ANA）、抗Ro和抗La；通过聚合酶链反应（PCR）和寡核苷酸分型测定人类白细胞抗原DR（HLA-DR）。采用Larsen评分法评估手足X线片。该研究纳入了106例患者，其中94例女性，12例男性；平均年龄为50.3±11.4岁，平均病程为11.2±6.8年。主要关节外表现为皮下结节、干眼症和口干症；75.5%的患者RF阳性。12.2%的患者检测到抗Ro抗体。比较抗Ro抗体阳性和阴性的患者时，未观察到任何研究变量有显著差异。根据我们的结果，抗Ro抗体在RA患者中缺乏临床相关性。
