Wild T F, Bernard A, Spehner D, Villeval D, Drillien R
Unité d'Immunologie et Stratégie Vaccinale, Institut Pasteur, Lyon, France.
Vaccine. 1993;11(4):438-44. doi: 10.1016/0264-410x(93)90285-6.
Measles and canine distemper are caused by serologically related viruses. Although dogs immunized with measles virus (MV) do not elicit canine distemper virus (CDV) neutralizing antibodies, they are protected against the fatal disease. To investigate the potential role of the MV antigens in protection against CDV, we have immunized mice with vaccinia virus (VV) recombinants expressing the MV haemagglutinin (HA), fusion (F), nucleoprotein (NP) and matrix (M) antigens and challenged them with CDV. A partial protection was observed with the VV recombinants expressing the F, NP and M antigens, but not the HA. In contrast, immunization with a VV recombinant expressing the CDV F protein completely protected mice from CDV.
麻疹和犬瘟热由血清学相关病毒引起。尽管用麻疹病毒（MV）免疫的犬不会产生犬瘟热病毒（CDV）中和抗体，但它们能抵御这种致命疾病。为了研究MV抗原在抵御CDV中的潜在作用，我们用表达MV血凝素（HA）、融合蛋白（F）、核蛋白（NP）和基质蛋白（M）抗原的痘苗病毒（VV）重组体免疫小鼠，并用CDV对其进行攻击。表达F、NP和M抗原的VV重组体可观察到部分保护作用，但表达HA的重组体则没有。相比之下，用表达CDV F蛋白的VV重组体免疫可使小鼠完全免受CDV感染。
