合成肽揭示的中性粒细胞趋化性、溶酶体酶分泌和吞噬作用的一些相互关系。
Some interrelations of neutrophil chemotaxis, lysosomal enzyme secretion, and phagocytosis as revealed by synthetic peptides.
作者信息
Becker E L
出版信息
Am J Pathol. 1976 Nov;85(2):385-94.
Abstract
Synthetic oligopeptides of appropriate structure stimulate neutrophil random locomotion, chemotaxis, lysosomal enzyme secretion, and phagocytosis. The structure-activity relationships found for enhanced migration and lysosomal enzyme secretion strongly suggest that the peptides bind to a structurally specific receptor on the neutrophil surface. It is further suggested that the binding of a peptide to the same receptor initiates all of these neutrophil functions. It is postulated that this is accomplished by the receptor-peptide combination initiating a series of parallel but coordinated and interdependent biochemical sequences leading to either microfilament or microtubule activation in addition to other processes. The various functions of the neutrophil differentially utilize the microfilament and microtubule systems.
摘要
具有适当结构的合成寡肽可刺激中性粒细胞的随机运动、趋化性、溶酶体酶分泌和吞噬作用。在增强迁移和溶酶体酶分泌方面发现的构效关系强烈表明，这些肽与中性粒细胞表面的结构特异性受体结合。进一步表明，肽与同一受体的结合启动了所有这些中性粒细胞功能。据推测，这是通过受体 - 肽复合物启动一系列平行但协调且相互依存的生化序列来实现的，除其他过程外，这些序列还会导致微丝或微管激活。中性粒细胞的各种功能以不同方式利用微丝和微管系统。
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