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Some interrelations of neutrophil chemotaxis, lysosomal enzyme secretion, and phagocytosis as revealed by synthetic peptides.合成肽揭示的中性粒细胞趋化性、溶酶体酶分泌和吞噬作用的一些相互关系。
Am J Pathol. 1976 Nov;85(2):385-94.
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Cell biology of leukocyte abnormalities--membrane and cytoskeletal function in normal and defective cells. A review.白细胞异常的细胞生物学——正常细胞与缺陷细胞中的膜和细胞骨架功能。综述
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本文引用的文献

1
Colchicine inhibition of chemotaxis.秋水仙碱对趋化性的抑制作用。
Arthritis Rheum. 1965 Oct;8(5):757-64. doi: 10.1002/art.1780080438.
2
Crystal-induced arthritis.晶体性关节炎
Postgrad Med. 1969 Jan;45(1):87-93. doi: 10.1080/00325481.1969.11696985.
3
Altered movement of endosomes in colchicine-treated cultured macrophages.秋水仙碱处理的培养巨噬细胞中内体运动的改变。
Exp Cell Res. 1971 Feb;64(2):430-8. doi: 10.1016/0014-4827(71)90097-8.
4
Effects of cytochalasin B on polymorphonuclear leucocyte locomotion, phagocytosis and glycolysis.细胞松弛素B对多形核白细胞运动、吞噬作用及糖酵解的影响。
Exp Cell Res. 1972 Aug;73(2):383-93. doi: 10.1016/0014-4827(72)90062-6.
5
Phagocytosis in chronic granulomatous disease and the Chediak-Higashi syndrome.慢性肉芽肿病和切-东综合征中的吞噬作用。
N Engl J Med. 1972 Jan 20;286(3):120-3. doi: 10.1056/NEJM197201202860302.
6
The regulatory role of divalent cations in human granulocyte chemotaxis. Evidence for an association between calcium exchanges and microtubule assembly.二价阳离子在人粒细胞趋化作用中的调节作用。钙交换与微管组装之间关联的证据。
J Cell Biol. 1974 Sep;62(3):594-609. doi: 10.1083/jcb.62.3.594.
7
The ability of chemotactic factors to induce lysosomal enzyme release. II. The mechanism of release.趋化因子诱导溶酶体酶释放的能力。II. 释放机制。
J Immunol. 1974 Jun;112(6):2055-62.
8
Phagocytosis by human blood leukocytes measured by the uptake of 131I-labeled human serum albumin: inhibitory and stimulatory effects of cytochalasin B.通过摄取¹³¹I标记的人血清白蛋白测定人血白细胞的吞噬作用：细胞松弛素B的抑制和刺激作用
Yale J Biol Med. 1973 Jun;46(3):177-89.
9
Neutrophil actin dysfunction and abnormal neutrophil behavior.中性粒细胞肌动蛋白功能障碍与中性粒细胞行为异常。
N Engl J Med. 1974 Nov 21;291(21):1093-9. doi: 10.1056/NEJM197411212912101.
10
The ability of chemotactic factors to induce lysosomal enzyme release. I. The characteristics of the release, the importance of surfaces and the relation of enzyme release to chemotactic responsiveness.趋化因子诱导溶酶体酶释放的能力。I. 释放的特征、表面的重要性以及酶释放与趋化反应性的关系。
J Immunol. 1974 Jun;112(6):2047-54.

合成肽揭示的中性粒细胞趋化性、溶酶体酶分泌和吞噬作用的一些相互关系。

Some interrelations of neutrophil chemotaxis, lysosomal enzyme secretion, and phagocytosis as revealed by synthetic peptides.

作者信息

Becker E L

出版信息

Am J Pathol. 1976 Nov;85(2):385-94.

PMID:793409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2032572/
Abstract

Synthetic oligopeptides of appropriate structure stimulate neutrophil random locomotion, chemotaxis, lysosomal enzyme secretion, and phagocytosis. The structure-activity relationships found for enhanced migration and lysosomal enzyme secretion strongly suggest that the peptides bind to a structurally specific receptor on the neutrophil surface. It is further suggested that the binding of a peptide to the same receptor initiates all of these neutrophil functions. It is postulated that this is accomplished by the receptor-peptide combination initiating a series of parallel but coordinated and interdependent biochemical sequences leading to either microfilament or microtubule activation in addition to other processes. The various functions of the neutrophil differentially utilize the microfilament and microtubule systems.

摘要

具有适当结构的合成寡肽可刺激中性粒细胞的随机运动、趋化性、溶酶体酶分泌和吞噬作用。在增强迁移和溶酶体酶分泌方面发现的构效关系强烈表明，这些肽与中性粒细胞表面的结构特异性受体结合。进一步表明，肽与同一受体的结合启动了所有这些中性粒细胞功能。据推测，这是通过受体 - 肽复合物启动一系列平行但协调且相互依存的生化序列来实现的，除其他过程外，这些序列还会导致微丝或微管激活。中性粒细胞的各种功能以不同方式利用微丝和微管系统。