BTB结构域主要存在于锌指蛋白中，它定义了一个进化上保守的家族，其中包括果蝇中几个受发育调控的基因。
The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila.
作者信息
Zollman S, Godt D, Privé G G, Couderc J L, Laski F A
机构信息
Molecular Biology Institute, University of California, Los Angeles 90024-1570.
出版信息
Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10717-21. doi: 10.1073/pnas.91.22.10717.
The Drosophila bric à brac protein and the transcriptional regulators encoded by tramtrack and Broad-Complex contain a highly conserved domain of approximately 115 amino acids, which we have called the BTB domain. We have identified six additional Drosophila genes that encode this domain. Five of these genes are developmentally regulated, and one of them appears to be functionally related to bric à brac. The BTB domain defines a gene family with an estimated 40 members in Drosophila. This domain is found primarily at the N terminus of zinc finger proteins and is evolutionarily conserved from Drosophila to mammals.
果蝇的bric à brac蛋白以及由tramtrack和Broad-Complex编码的转录调节因子包含一个约115个氨基酸的高度保守结构域，我们将其称为BTB结构域。我们又鉴定出另外六个果蝇基因，它们也编码这个结构域。其中五个基因受发育调控，而且其中一个基因在功能上似乎与bric à brac相关。BTB结构域定义了一个基因家族，在果蝇中估计有40个成员。这个结构域主要位于锌指蛋白的N端，从果蝇到哺乳动物在进化上是保守的。
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