Houpt T R
Department of Physiology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
Physiol Behav. 1994 Aug;56(2):311-7. doi: 10.1016/0031-9384(94)90200-3.
Pressures were measured with miniature transducers positioned within the gastric lumen of six young pigs, 20-40 kg, eating and drinking operantly. The pigs were free to move about, lie down, sleep, eat, and drink without disturbance. 1) At the end of 4-5-h fasts (with no drinking), mean pressure within the stomach was 12 cm H2O, then rose during 22-min eating bouts to 22 cm H2O. 2) At the end of 16-18-h periods of food and water deprivation, intragastric pressure was 9 cm H2O. When water was drunk, pressures rose only to 13 cm H2O, then fell. When food was then eaten, pressures rose during 29-min meals to 22 cm H2O. 3) During spontaneous eating and drinking, intermeal pressures were maintained at 22-25 cm H2O, fell by 4-5 cm H2O just as eating or drinking began, then rose slowly, but only to the preingestive pressure level by the end of the bout. These results indicate that during spontaneous eating and drinking, gastric distention per se plays a smaller direct role in causing satiety than it does during meals ingested after a period of food deprivation.
使用微型传感器测量了6头体重20 - 40千克的幼猪胃腔内的压力，这些猪通过操作性条件反射进食和饮水。猪可以自由活动、躺下、睡觉、进食和饮水而不受干扰。1）在禁食4 - 5小时（不饮水）结束时，胃内平均压力为12厘米水柱，然后在22分钟的进食过程中升至22厘米水柱。2）在禁食16 - 18小时（食物和水都不摄入）结束时，胃内压力为9厘米水柱。当饮水时，压力仅升至13厘米水柱，然后下降。当随后进食时，在29分钟的进餐过程中压力升至22厘米水柱。3）在自发进食和饮水过程中，餐间压力维持在22 - 25厘米水柱，在进食或饮水开始时下降4 - 5厘米水柱，然后缓慢上升，但在进食结束时仅升至进食前的压力水平。这些结果表明，在自发进食和饮水过程中，胃扩张本身在引起饱腹感方面所起的直接作用比在一段时间食物剥夺后进食时要小。
