脓毒症患者的血小板活化因子乙酰水解酶和花生四烯酸代谢物水平

PAF acetylhydrolase and arachidonic acid metabolite levels in patients with sepsis.

作者信息

Takakuwa T, Endo S, Nakae H, Kikichi M, Inada K, Yoshida M

机构信息

Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.

出版信息

Res Commun Chem Pathol Pharmacol. 1994 Jun;84(3):283-90.

PMID:7938902

Abstract

To examine the relationship between arachidonic acid metabolism and sepsis, we determined the blood concentration of platelet-activating factor acetylhydrolase (PAFAH) and of arachidonic acid cascade substances, leukotriene B4 (LTB4), thromboxane B2 (TXB2), and 6-keto-prostaglandin Fla (PGF1a), in patients with clinical sepsis. Blood concentrations of PAFAH, LTB4, TXB2 and PGF1a at the time of the initial diagnosis of sepsis were 23.9 +/- 9.7 nmol/min/mL, 90.4 +/- 31.5 pg/mL, 55.3 +/- 44.1 pg/mL and 22.3 +/- 11.9 pg/mL, respectively. There was a significant correlation between the blood PAFAH and LTB4 concentration (r = 0.520, p = 0.0033) and the diagnosis of sepsis. There also was a significant correlation between the blood PAFAH and TXB2 concentration (r = 0.460, p = 0.0311). There was no correlation between the blood PAFAH and PGF1a concentrations. Elevated LTB4 and TXB2 concentrations showed a significant correlation with the PAFAH concentration in patients with sepsis, suggesting a direct relationship between these substances.

摘要

为研究花生四烯酸代谢与脓毒症之间的关系，我们测定了临床脓毒症患者血小板活化因子乙酰水解酶（PAFAH）以及花生四烯酸级联物质白三烯B4（LTB4）、血栓素B2（TXB2）和6-酮-前列腺素F1α（PGF1α）的血药浓度。脓毒症初诊时PAFAH、LTB4、TXB2和PGF1α的血药浓度分别为23.9±9.7 nmol/min/mL、90.4±31.5 pg/mL、55.3±44.1 pg/mL和22.3±11.9 pg/mL。血中PAFAH与LTB4浓度之间以及与脓毒症诊断之间存在显著相关性（r = 0.520，p = 0.0033）。血中PAFAH与TXB2浓度之间也存在显著相关性（r = 0.460，p = 0.0311）。血中PAFAH与PGF1α浓度之间无相关性。脓毒症患者中LTB4和TXB2浓度升高与PAFAH浓度呈显著相关，提示这些物质之间存在直接关系。