真核生物中mRNA降解的机制。

Mechanisms of mRNA degradation in eukaryotes.

作者信息

Decker C J, Parker R

机构信息

Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721.

出版信息

Trends Biochem Sci. 1994 Aug;19(8):336-40. doi: 10.1016/0968-0004(94)90073-6.

DOI:10.1016/0968-0004(94)90073-6

PMID:7940679

Abstract

Recent experiments have identified distinct mechanisms of eukaryotic RNA turnover. In one mechanism, deadenylation triggers decapping, exposing the messenger RNA to 5' to 3' degradation. This pathway may act at different rates on the majority of messenger RNAs. There are also degradation mechanisms, such as endonucleolytic cleavage, limited to messenger RNAs containing specific sequence elements.

摘要

近期的实验已经确定了真核生物RNA周转的不同机制。在一种机制中，去腺苷酸化引发脱帽，使信使RNA暴露于5'至3'降解。这条途径可能以不同速率作用于大多数信使RNA。也存在一些降解机制，比如核酸内切酶切割，它仅限于含有特定序列元件的信使RNA。