Knight J A, Searles D A
Pathology and Laboratory Medicine Service, Salt Lake VA Medical Center.
Ann Clin Lab Sci. 1994 Jul-Aug;24(4):294-301.
Since the introduction of acid-citrate-dextrose (ACD) in 1947 to anticoagulate and preserve whole blood for transfusion, various other improved nutrient formulas have been introduced that have significantly increased the viability and lifespan of stored erythrocytes. More recently, several studies involving lipid peroxidation have been reported in an attempt to understand alternative mechanisms that might lead to a further increase in red cell viability and extend the storage life of whole blood. In the current study, the effects of a variety of substances are reported whose antioxidant mechanisms differ; they include the transition metals manganese and zinc, the metal chelator phytic acid, and the free radical scavengers N-acetylcysteine, mannitol, uric acid, 1,3 dimethyluric acid, and quercetin. All but N-acetylcysteine, uric acid, and phytic acid were consistently effective in decreasing lipid peroxidation in stored red cells.
自1947年引入酸-枸橼酸盐-葡萄糖（ACD）用于抗凝和保存全血以供输血以来，已推出了各种其他改良的营养配方，这些配方显著提高了储存红细胞的活力和寿命。最近，有几项关于脂质过氧化的研究报告，试图了解可能导致红细胞活力进一步提高和延长全血储存寿命的替代机制。在当前的研究中，报告了多种物质的作用，其抗氧化机制各不相同；它们包括过渡金属锰和锌、金属螯合剂植酸以及自由基清除剂N-乙酰半胱氨酸、甘露醇、尿酸、1,3-二甲基尿酸和槲皮素。除N-乙酰半胱氨酸、尿酸和植酸外，所有物质在降低储存红细胞中的脂质过氧化方面均持续有效。
