Nickoloff B J, Turka L A
Dept of Pathology, University of Michigan, Ann Arbor 48109-0602.
Immunol Today. 1994 Oct;15(10):464-9. doi: 10.1016/0167-5699(94)90190-2.
T-cell activation in the absence of co-stimulatory signals can lead to induction of anergy. Professional antigen-presenting cells (APCs) of bone marrow origin, such as macrophages and dendritic cells, can provide co-stimulation through molecules such as B7-1 and B7-2. In addition, cells of epithelial origin can function as 'non-professional' APCs when activated. In these circumstances, the functional consequences of the T cell-APC interaction may differ, perhaps due to the nature of the co-stimulatory pathways utilized and/or the cytokines encountered by the T cell. Here, Brian Nickoloff and Laurence Turka suggest that these differences may be important in regulating immune responses to local antigens and also in maintaining self-tolerance.
在缺乏共刺激信号的情况下，T细胞活化可导致无反应性的诱导。骨髓来源的专职抗原呈递细胞（APC），如巨噬细胞和树突状细胞，可通过B7-1和B7-2等分子提供共刺激。此外，上皮来源的细胞在活化时可作为“非专职”APC发挥作用。在这些情况下，T细胞与APC相互作用的功能后果可能不同，这可能是由于所利用的共刺激途径的性质和/或T细胞遇到的细胞因子所致。在此，布莱恩·尼科洛夫和劳伦斯·图尔卡指出，这些差异可能在调节对局部抗原的免疫反应以及维持自身耐受性方面具有重要意义。
