Faraj B A, Davis D C, Camp V M, Mooney A J, Holloway T
Department of Radiology (Division of Nuclear Medicine), Emory University School of Medicine, Atlanta, GA 30322.
Alcohol. 1994 Jul-Aug;11(4):337-42. doi: 10.1016/0741-8329(94)90101-5.
This study investigated the effect of cocaine abuse on peripheral dopamine and its tetrahydroisoquinoline metabolite salsolinol in chronic alcoholics. Specifically, the concentration of dopamine sulfate and salsolinol sulfate was measured in plasma samples obtained from the blood of a group of alcoholics (n = 40) and alcoholics with cocaine dependence (n = 55). The concentrations of sulfoconjugated dopamine and salsolinol were measured by a radioenzymatic technique. The results of this study showed that chronic alcoholics (627 +/- 195 pg/ml) and alcoholics with cocaine addiction (409 +/- 76 pg/ml) had significantly (p < 0.05) elevated levels of salsolinol sulfate (mean +/- SEM) in their plasma as compared to controls (99.5 +/- 7.5 pg/ml). However, alcoholics with cocaine dependence produced significantly (p < 0.01) higher concentration of dopamine sulfate in their plasma (7520 +/- 1299 pg/ml) as compared to chronic alcoholics (3896 +/- 438 pg/ml) and controls (2124 +/- 104 pg/ml). Differences in plasma dopamine sulfate among alcoholics with cocaine dependence vs. alcoholics without cocaine dependence may be interpreted as a reflection of increased extracellular dopamine metabolism associated with chronic cocaine exposure.
本研究调查了可卡因滥用对慢性酒精中毒患者外周多巴胺及其四氢异喹啉代谢产物萨索林醇的影响。具体而言，测量了从一组酒精中毒患者（n = 40）和可卡因依赖的酒精中毒患者（n = 55）血液中获取的血浆样本中硫酸多巴胺和硫酸萨索林醇的浓度。通过放射酶法测量硫酸化多巴胺和萨索林醇的浓度。本研究结果表明，与对照组（99.5±7.5 pg/ml）相比，慢性酒精中毒患者（627±195 pg/ml）和可卡因成瘾的酒精中毒患者（409±76 pg/ml）血浆中硫酸萨索林醇水平显著升高（p < 0.05）。然而，与慢性酒精中毒患者（3896±438 pg/ml）和对照组（2124±104 pg/ml）相比，可卡因依赖的酒精中毒患者血浆中硫酸多巴胺浓度显著更高（p < 0.01）（7520±1299 pg/ml）。可卡因依赖的酒精中毒患者与无可卡因依赖的酒精中毒患者血浆硫酸多巴胺的差异可能被解释为与长期接触可卡因相关的细胞外多巴胺代谢增加的反映。
