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Failure of cytarabine and increased JC virus-DNA burden in the cerebrospinal fluid of patients with AIDS-related progressive multifocal leucoencephalopathy.

作者信息

Antinori A, De Luca A, Ammassari A, Cingolani A, Murri R, Colosimo G, Roselli R, Scerrati M, Tamburrini E

出版信息

AIDS. 1994 Jul;8(7):1022-4.

PMID:7946093
Abstract
摘要

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Failure of cytarabine and increased JC virus-DNA burden in the cerebrospinal fluid of patients with AIDS-related progressive multifocal leucoencephalopathy.阿糖胞苷治疗失败与艾滋病相关进行性多灶性白质脑病患者脑脊液中JC病毒DNA载量增加
AIDS. 1994 Jul;8(7):1022-4.
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JC virus detection in the cerebrospinal fluid of AIDS patients with progressive multifocal leucoencephalopathy and monitoring of the antiviral treatment by a PCR method.采用聚合酶链反应(PCR)方法检测进行性多灶性白质脑病艾滋病患者脑脊液中的JC病毒并监测抗病毒治疗情况。
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Quantification of JC virus DNA in the cerebrospinal fluid of patients with human immunodeficiency virus-associated progressive multifocal leukoencephalopathy--a longitudinal study.人类免疫缺陷病毒相关进行性多灶性白质脑病患者脑脊液中 JC 病毒 DNA 的定量分析——一项纵向研究
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Clinical and virological monitoring during treatment with intrathecal cytarabine in patients with AIDS-associated progressive multifocal leukoencephalopathy.
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Highly active antiretroviral therapy does not improve survival of patients with high JC virus load in the cerebrospinal fluid at progressive multifocal leukoencephalopathy diagnosis.在进行性多灶性白质脑病诊断时,高效抗逆转录病毒疗法并不能提高脑脊液中JC病毒载量高的患者的生存率。
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[The diagnosis of viral infections in the central nervous system in AIDS and related pathologies by the polymerase chain reaction in the cerebrospinal fluid].
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Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain.进行性多灶性白质脑病,即人类大脑中由 JC 病毒引起的脱髓鞘疾病的分子生物学、流行病学和发病机制。
Clin Microbiol Rev. 2012 Jul;25(3):471-506. doi: 10.1128/CMR.05031-11.
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Progressive multifocal leukoencephalopathy and other forms of JC virus disease.
进行性多灶性白质脑病和其他形式的 JC 病毒病。
Nat Rev Neurol. 2010 Dec;6(12):667-79. doi: 10.1038/nrneurol.2010.164.
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Molecular regulation of JC virus tropism: insights into potential therapeutic targets for progressive multifocal leukoencephalopathy.JC 病毒嗜性的分子调控:对进行性多灶性白质脑病潜在治疗靶点的深入了解。
J Neuroimmune Pharmacol. 2010 Sep;5(3):404-17. doi: 10.1007/s11481-010-9203-1. Epub 2010 Apr 17.
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Interferon- alpha and - beta restrict polyomavirus JC replication in primary human fetal glial cells: implications for progressive multifocal leukoencephalopathy therapy.α干扰素和β干扰素可限制多瘤病毒JC在原代人胎儿神经胶质细胞中的复制:对进行性多灶性白质脑病治疗的意义。
J Infect Dis. 2007 Sep 1;196(5):712-8. doi: 10.1086/520518. Epub 2007 Jul 20.
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Opportunistic infections of the CNS in patients with AIDS: diagnosis and management.艾滋病患者中枢神经系统的机会性感染:诊断与管理
CNS Drugs. 2003;17(12):869-87. doi: 10.2165/00023210-200317120-00002.
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Dual qualitative-quantitative nested PCR for detection of JC virus in cerebrospinal fluid: high potential for evaluation and monitoring of progressive multifocal leukoencephalopathy in AIDS patients receiving highly active antiretroviral therapy.用于检测脑脊液中JC病毒的双重定性-定量巢式PCR:在接受高效抗逆转录病毒治疗的艾滋病患者中评估和监测进行性多灶性白质脑病的巨大潜力。
J Clin Microbiol. 1999 Mar;37(3):724-8. doi: 10.1128/JCM.37.3.724-728.1999.
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Activities of various compounds against murine and primate polyomaviruses.多种化合物对鼠类和灵长类多瘤病毒的活性。
Antimicrob Agents Chemother. 1997 Mar;41(3):587-93. doi: 10.1128/AAC.41.3.587.
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Genotype profile of human polyomavirus JC excreted in urine of immunocompetent individuals.免疫功能正常个体尿液中排泄的人多瘤病毒JC的基因型谱。
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Improved detection of JC virus DNA in cerebrospinal fluid for diagnosis of AIDS-related progressive multifocal leukoencephalopathy.改进脑脊液中JC病毒DNA检测以诊断艾滋病相关进行性多灶性白质脑病。
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