Huang X, Ren P, Wen A D
Xijing Hospital, Fourth Military Medical University, Xi'an.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1994 Mar;14(3):159-61, 134.
In this experiment, the essence of Spleen Deficiency Syndrome (SDS) was explored with the rat model of SDS using tetramethylpyrazine (TMP). 120 Wistar rats were divided into two groups, 60 each for control and test group, they were treated with normal saline and reserpine respectively. The hemorheological parameters were also studied in 6 each of both groups. The pharmacokinetic properties were investigated in the remaining control group and test group.
(1) Two-compartment open model of the control group was turned into that of one-compartment in test group; (2) The SDS model significantly affected the absorption and distribution of TMP in rats. AUC was much higher and serum concentration of TMP increased significantly than that of control. Hemorheological parameters (viscosity of whole blood, fibrinogen, etc.) increased significantly (P < 0.05-0.01), it demonstrated that the SDS model was in a state of Blood Stasis. It might be one of the pharmacokinetic mechanisms of TMP in the SDS model of rats.
在本实验中，使用川芎嗪（TMP）通过脾虚综合征（SDS）大鼠模型探究脾虚综合征的本质。120只Wistar大鼠分为两组，对照组和试验组各60只，分别用生理盐水和利血平处理。两组各取6只大鼠研究血液流变学参数。在其余的对照组和试验组中研究药代动力学性质。
（1）对照组的二室开放模型转变为试验组的一室模型；（2）SDS模型显著影响TMP在大鼠体内的吸收和分布。AUC更高，TMP的血清浓度比对照组显著升高。血液流变学参数（全血粘度、纤维蛋白原等）显著升高（P<0.05 - 0.01），表明SDS模型处于血瘀状态。这可能是TMP在大鼠SDS模型中的药代动力学机制之一。
