Yoshihara K, Nemoto S, Nagata M
Tokyo College of Pharmacy, Japan.
Biol Pharm Bull. 1994 Jun;17(6):840-2. doi: 10.1248/bpb.17.840.
Hydroxylysylpyridinoline (HP), an intermolecular cross-linking amino acid, is present only in bone and cartilage collagen. We examined urinary HP levels in order to assess bone collagen metabolism using HPLC. Urinary HP excretion levels (nmol/mmol creatinine) of healthy control groups gradually increased with aging. Urinary HP excretion levels of females were higher than those of age-adjusted males. On the other hand, the urinary excretion levels of HP in osteoporotic patients were significantly higher than those of age and sex-adjusted controls. It is suggested that the determination of urinary HP excretion levels is useful in the clinical evaluation of metabolic bone diseases, especially osteoporosis.
羟赖氨酰吡啶啉（HP）是一种分子间交联氨基酸，仅存在于骨骼和软骨胶原蛋白中。我们使用高效液相色谱法检测尿HP水平，以评估骨胶原代谢。健康对照组的尿HP排泄水平（nmol/mmol肌酐）随年龄增长而逐渐升高。女性的尿HP排泄水平高于年龄匹配的男性。另一方面，骨质疏松症患者的尿HP排泄水平显著高于年龄和性别匹配的对照组。提示测定尿HP排泄水平有助于代谢性骨病尤其是骨质疏松症的临床评估。
