DX-9386对衰老加速小鼠的抗衰老作用。
Anti-aging effect of DX-9386 in senescence accelerated mouse.
作者信息
Zhang Y, Takashina K, Saito H, Nishiyama N
机构信息
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
出版信息
Biol Pharm Bull. 1994 Jun;17(6):866-8. doi: 10.1248/bpb.17.866.
The effects of DX-9386, a traditional Chinese prescription (ginseng, acorus, polygala and hoelen) were studied on life span, the degree of senescence, motor activity and the antibody production response in senescence accelerated mouse (SAM). DX-9386-containing food was given to SAM for 13 consecutive months from 2 months of age. DX-9386 significantly prolonged the life span of SAM, prevented body weight decrease with aging and tended to improve the senile syndrome. The motor activity of SAMP8 was higher than that of SAMR1, and DX-9386 tended to increase the activity in SAMP8. The in vivo antibody production was markedly decreased in SAMP8 and DX-9386 showed no ameliorating effect on that. These results suggest that DX-9386 has anti-aging impact.
研究了中药复方 DX - 9386（人参、菖蒲、远志和茯苓）对衰老加速小鼠（SAM）的寿命、衰老程度、运动活性及抗体产生反应的影响。从 2 月龄开始，连续 13 个月给 SAM 喂食含 DX - 9386 的食物。DX - 9386 显著延长了 SAM 的寿命，防止体重随衰老而下降，并倾向于改善衰老综合征。SAMP8 的运动活性高于 SAMR1，DX - 9386 倾向于增加 SAMP8 的活性。SAMP8 的体内抗体产生明显减少，DX - 9386 对此无改善作用。这些结果表明 DX - 9386 具有抗衰老作用。
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