McNamee R, Braganza J M, Hogg J, Leck I, Rose P, Cherry N M
Centre for Occupational Health, University of Manchester.
Occup Environ Med. 1994 Sep;51(9):631-7. doi: 10.1136/oem.51.9.631.
To investigate the hypothesis that hydrocarbon exposure is a risk factor for chronic pancreatitis.
102 cases of chronic pancreatitis and 204 age and sex matched referents were interviewed about their occupational histories, alcohol and cigarette consumption, and diet. Exposure to hydrocarbons was inferred from interview responses by four assessors who were blind to disease state, and these data were then summarised by a cumulative hydrocarbon exposure (CHE) score.
After adjustment for alcohol, cigarettes, dietary antioxidants, and social class, odds ratios for low CHE scores were 1.20 (90% CI: 0.62-2.35) and 2.67 (90% CI: 1.22-5.87) for high scores. A test for trend with level of exposure among only those who had exposure scores > 0 gave p = 0.09. Analysis by type of hydrocarbon was limited to four exposures for each of which there were at least 20 exposed patients. The adjusted OR for paint solvents (any level) was 0.96 (90% CI: 0.48-1.93); for diesel exhaust fumes OR = 2.66 (90% CI: 1.05-6.73); for petrochemicals OR = 1.82 (90% CI: 0.80-4.11); and for chlorinated solvents OR = 1.49 (90% CI: 0.58-3.81).
These results support the original hypothesis. Further studies are needed to confirm or refute the findings here and to clarify the types of hydrocarbon involved.
调查碳氢化合物暴露是慢性胰腺炎危险因素这一假设。
对102例慢性胰腺炎患者和204例年龄及性别匹配的对照者进行访谈，了解他们的职业史、饮酒和吸烟情况以及饮食。由四名对疾病状态不知情的评估人员根据访谈回答推断碳氢化合物暴露情况，然后通过累积碳氢化合物暴露（CHE）评分对这些数据进行汇总。
在对酒精、香烟、膳食抗氧化剂和社会阶层进行调整后，低CHE评分的比值比为1.20（90%可信区间：0.62 - 2.35），高评分的比值比为2.67（90%可信区间：1.22 - 5.87）。仅对暴露评分>0的人群按暴露水平进行趋势检验，p = 0.09。按碳氢化合物类型分析仅限于四种暴露情况，每种情况至少有20例暴露患者。油漆溶剂（任何水平）的调整后比值比为0.96（90%可信区间：0.48 - 1.93）；柴油废气的比值比为2.66（90%可信区间：1.05 - 6.73）；石化产品的比值比为1.82（90%可信区间：0.80 - 4.11）；氯化溶剂的比值比为1.49（90%可信区间：0.58 - 3.81）。
这些结果支持原假设。需要进一步研究来证实或反驳此处的发现，并明确所涉及的碳氢化合物类型。
