Iarilin A A, Sharova N I, Kuz'menok O I, Titova L D, Kotina N I, Oradovskaia I V
Radiats Biol Radioecol. 1994 Jul-Oct;34(4-5):603-10.
Increased level of serum thymic activity and normal serum concentration of alpha-1-thymosin were revealed in inhabitants of region polluted by radionuclides after Chernobyl accident (settlement Vyshkov, Bryansk region). In the same population the serum level of autoantibodies, reacting with thymic epithelial cell line was elevated. Similar but less prominent alterations were found in population of radiologically pure region (settlement Potchep). Revealed autoantibodies had mainly IgM isotype. The negative correlation exists between levels of autoantibodies and serum thymic activity. Sera of persons from the control group and one half of Vyshkov inhabitants reacted with thymic epithelial cells of both human and mouse origin; in other half of Vyshkov inhabitants species-specific autoantibodies were revealed. We propose that correlated increase of antithymic autoantibody level and decrease of serum thymic activity are the consequence and indicators of unfavorable ecological conditions; however the contribution of radiation factor to their induction can not be estimated on the basis of presented data.
切尔诺贝利事故后受放射性核素污染地区（布良斯克州维什科夫居民点）居民的血清胸腺活性水平升高，α-1胸腺素的血清浓度正常。在同一人群中，与胸腺上皮细胞系发生反应的自身抗体血清水平升高。在放射学上纯净地区（波切普居民点）的人群中也发现了类似但不太明显的变化。所发现的自身抗体主要为IgM同种型。自身抗体水平与血清胸腺活性之间存在负相关。对照组人员的血清以及维什科夫居民一半的血清与人和小鼠来源的胸腺上皮细胞发生反应；在维什科夫居民的另一半中发现了物种特异性自身抗体。我们认为抗胸腺自身抗体水平的相关升高和血清胸腺活性的降低是不利生态条件的结果和指标；然而，根据现有数据无法估计辐射因素对其诱导的作用。
