Yarilin A A, Belyakov I M, Kusmenok O I, Arshinov V Y, Simonova A V, Nadezhina N M, Gnezditskaya E V
Institute of Immunology, Ministry of Public Health of Russia, Moscow, Russia.
Int J Radiat Biol. 1993 Apr;63(4):519-28. doi: 10.1080/09553009314550681.
T cell number, serum concentrations of thymic hormones and anti-epithelial autoantibodies were studied in people affected at Chernobyl NPP. Group 1 took part in the clearing-up operation and had no clinical manifestations of acute radiation sickness. Group 2 worked at the NPP during the accident; they survived acute radiation sickness (degree I-II, subgroup 2a; degree III-IV, subgroup 2b). The total doses of external radiation were 0.1-0.5 Gy in group 1, up to 4 Gy in subgroup 2a and up to 9 Gy in subgroup 2b. Total T cell number, serum thymic activity and alpha 1-thymosin concentration were decreased in all groups of affected persons. CD8+ cell number decreased only in group 1; CD4+ cell number in subgroup 2b. A decrease in thymic hormone level was most prominent in subgroup 2b. The titres of anti-epithelial antibodies were increased in all groups of affected persons independently of radiation dose. The titres were higher in patients with subnormal levels of alpha 1-thymosin. It has been proposed that radiation alters the function of thymic epithelial cells by direct action and/or through indirect mechanisms including participation of autoantibodies. The observed complex of alterations is similar to that in the normal process of immunological ageing.
对受切尔诺贝利核电站事故影响的人群的T细胞数量、胸腺激素血清浓度和抗上皮自身抗体进行了研究。第1组参与了清理行动，没有急性放射病的临床表现。第2组在事故发生时在核电站工作；他们从急性放射病中幸存下来（I-II度，2a亚组；III-IV度，2b亚组）。第1组的外照射总剂量为0.1-0.5 Gy，2a亚组高达4 Gy，2b亚组高达9 Gy。所有受影响人群组的总T细胞数量、血清胸腺活性和α1-胸腺素浓度均降低。CD8+细胞数量仅在第1组中减少；2b亚组中的CD4+细胞数量减少。胸腺激素水平的降低在2b亚组中最为明显。所有受影响人群组的抗上皮抗体滴度均升高，与辐射剂量无关。α1-胸腺素水平低于正常的患者滴度更高。有人提出，辐射通过直接作用和/或通过包括自身抗体参与在内的间接机制改变胸腺上皮细胞的功能。观察到的这种变化复合体与正常免疫衰老过程中的变化相似。
