通过pH区带精制逆流色谱法分离碱性氨基酸苄酯。
Separations of basic amino acid benzyl esters by pH-zone-refining counter-current chromatography.
作者信息
Ma Y, Ito Y
机构信息
Laboratory of Biophysical Chemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
出版信息
J Chromatogr A. 1994 Sep 2;678(2):233-40. doi: 10.1016/0021-9673(94)80470-2.
PMID:7951985
Abstract
pH-Zone-refining counter-current chromatography was applied to the separation of basic amino acid benzyl esters. The method uses a retainer base in the stationary phase to retain analytes in the column and an eluent acid to elute the analytes in the decreasing order of pKa and hydrophilicity. The preparative capability of the method is demonstrated in the separation of a 10-g quantity of the sample.
摘要
pH区带精制逆流色谱法用于分离碱性氨基酸苄酯。该方法在固定相中使用保留碱将分析物保留在柱中，并使用洗脱酸以pKa和亲水性的降序洗脱分析物。该方法的制备能力在10克样品的分离中得到了证明。
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