Brown H R, Pessolano T L, Nostro A F, Thormar H
Acta Neuropathol. 1985;65(3-4):195-201. doi: 10.1007/BF00686998.
Measles virus-specific immunoglobulin G (IgG) has been found in the brains of patients with subacute sclerosing panencephalitis (SSPE), a slowly progressing central nervous system (CNS) disease affecting children. IgG/albumin ratios indicate that the antibodies are probably synthesized in the CNS. In a ferret model system, protein A conjugated to horseradish peroxidase (PrAPx) was used to localize Ig's in brains of animals inoculated with a cell associated strain of SSPE. Ig's were found in plasma cells in various stages of antibody production both in perivascular inflammatory lesions and scattered throughout the cerebral cortex. These findings offer corroborative evidence that the Ig found in SSPE ferret brain and CSF is actively synthesized within the CNS. Antibody was also demonstrated in glial and neuronal cell bodies and processes and in postsynaptic profiles. These are the same sites where measles virus antigens are most frequently found and suggests the possibility of immune complex formation.
在亚急性硬化性全脑炎（SSPE）患者的大脑中发现了麻疹病毒特异性免疫球蛋白G（IgG），SSPE是一种影响儿童的进展缓慢的中枢神经系统（CNS）疾病。IgG/白蛋白比率表明这些抗体可能是在中枢神经系统中合成的。在雪貂模型系统中，将与辣根过氧化物酶偶联的蛋白A（PrAPx）用于在接种了细胞相关株SSPE的动物大脑中定位免疫球蛋白。在血管周围炎性病变和整个大脑皮层中散在的处于抗体产生不同阶段的浆细胞中发现了免疫球蛋白。这些发现提供了确证性证据，表明在SSPE雪貂大脑和脑脊液中发现的免疫球蛋白是在中枢神经系统内活跃合成的。在神经胶质细胞、神经元细胞体及其突起以及突触后结构中也证实了抗体的存在。这些正是最常发现麻疹病毒抗原的部位，并提示了形成免疫复合物的可能性。
