Le Jossic C, Ilyin G P, Loyer P, Glaise D, Cariou S, Guguen-Guillouzo C
INSERM U49, Unité de Recherches Hépatologiques, Hôpital Pontchaillou, Rennes, France.
Cancer Res. 1994 Dec 1;54(23):6065-8.
Id proteins are known as negative regulators of differentiation in various cell types. In this report, we show that the Id-1 gene was down-regulated during the development of rat liver. No Id-1 transcripts were detected in terminal differentiated hepatocytes. We have studied Id-1 expression in proliferating hepatocytes using an in vivo model of liver regeneration after partial hepatectomy and an in vitro growth factor-stimulated hepatocyte culture system. Strong activation of Id-1 was observed in mid-late G1 of the hepatocyte cell cycle at a time corresponding to a mitogen restriction point. These observations suggest that Id-1 is involved in the control of proliferation and differentiation in liver cells.
Id蛋白被认为是多种细胞类型中分化的负调节因子。在本报告中，我们表明Id-1基因在大鼠肝脏发育过程中表达下调。在终末分化的肝细胞中未检测到Id-1转录本。我们使用部分肝切除术后肝脏再生的体内模型和体外生长因子刺激的肝细胞培养系统，研究了增殖肝细胞中Id-1的表达。在与有丝分裂原限制点相对应的时间，在肝细胞周期的G1中后期观察到Id-1的强烈激活。这些观察结果表明，Id-1参与了肝细胞增殖和分化的调控。
