Waldenlind E, Ekbom K, Wetterberg L, Fanciullacci M, Marabini S, Sicuteri F, Polleri A, Murialdo G, Filippi U
Department of Neurology, Söder Hospital, Stockholm, Sweden.
Cephalalgia. 1994 Jun;14(3):199-204. doi: 10.1046/j.1468-2982.1994.014003199.x.
The circannual secretion of melatonin in 14 Swedish and 15 Italian patients suffering from episodic cluster headache was compared with 14 Swedish and 15 Italian healthy controls matched for sex and age. Overnight samples of urine were collected once a month from 8 to 14 months and kept at -20 degrees C until analysed with RIA. The melatonin concentrations in nocturnal urine were permanently low in cluster headache and there was no consistent change of the melatonin concentration in relation to cluster periods occurring during the study. There was no definitive circannual or infraannual rhythmicity of melatonin in patients or controls. Multiple analysis of variance with repeated measurements showed a significant effect of disease (p < 0.05), but not of time. Sex, geographical location, age, and smoking also had significant effects (p < 0.001) on the melatonin concentrations. Lower melatonin levels in cluster headache patients than in controls may in part be related to a larger number of smokers in the patient group. The relation between tobacco use and melatonin should be further studied.
对14名瑞典和15名意大利发作性丛集性头痛患者的褪黑素年度分泌情况与14名瑞典和15名意大利年龄及性别匹配的健康对照者进行了比较。从8至14个月，每月采集一次过夜尿液样本，并保存在-20摄氏度，直至用放射免疫分析法进行分析。丛集性头痛患者夜间尿液中的褪黑素浓度一直较低，且在研究期间，褪黑素浓度与丛集期之间没有一致的变化。患者或对照者均未出现明确的褪黑素年度或年度内节律。重复测量的多因素方差分析显示疾病有显著影响（p < 0.05），但时间没有。性别、地理位置、年龄和吸烟对褪黑素浓度也有显著影响（p < 0.001）。丛集性头痛患者的褪黑素水平低于对照者，这可能部分与患者组中吸烟者较多有关。吸烟与褪黑素之间的关系应进一步研究。
