Simms R W, Prout M N, Cohen A S
Arthritis Center, Boston University School of Medicine, MA 02118.
Baillieres Clin Rheumatol. 1994 Aug;8(3):627-34. doi: 10.1016/s0950-3579(05)80119-0.
The limited available epidemiological information on AL amyloidosis suggests that there may be differences between population-based studies and case series data with respect to variables such as age and racial patterns. Much more work in this area is required before specific aetiologic hypotheses can be tested. Most available data to approximate the epidemiology of AA amyloidosis are derived from autopsies. Most patients with AA amyloidosis die from causes other than amyloidosis, therefore mortality data based on death certificates is of limited value in AA amyloidosis. Case ascertainment in autopsy studies may be difficult due to the frequent lack of adequate histological controls. Establishment of registries for both AL and AA amyloidosis would facilitate epidemiological research in these disorders.
关于轻链（AL）淀粉样变性病有限的现有流行病学信息表明，在基于人群的研究和病例系列数据之间，可能在年龄和种族模式等变量方面存在差异。在能够检验特定病因假说之前，该领域还需要开展更多工作。用于估算继发性（AA）淀粉样变性病流行病学的大多数现有数据来自尸检。大多数AA淀粉样变性病患者死于淀粉样变性病以外的原因，因此基于死亡证明的死亡率数据在AA淀粉样变性病中价值有限。由于经常缺乏充分的组织学对照，尸检研究中的病例确定可能很困难。建立AL和AA淀粉样变性病登记处将有助于对这些疾病开展流行病学研究。
