水生植物的天然药物。IV. 泽泻根茎的成分。(2). 来自中国泽泻根茎的生物活性倍半萜类化合物泽泻醇、泽泻醇氧化物、东方泽泻醇A、B和C的立体结构。

Crude drugs from aquatic plants. IV. On the constituents of alismatis rhizoma. (2). Stereostructures of bioactive sesquiterpenes, alismol, alismoxide, orientalols A, B, and C, from Chinese alismatis rhizoma.

作者信息

Yoshikawa M, Yamaguchi S, Matsuda H, Kohda Y, Ishikawa H, Tanaka N, Yamahara J, Murakami N

机构信息

Kyoto Pharmaceutical University, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1994 Sep;42(9):1813-6. doi: 10.1248/cpb.42.1813.

DOI:10.1248/cpb.42.1813

PMID:7954931

Abstract

Following the characterization of the triterpene constituents in Chinese Alismatis Rhizoma, we investigated the chemical structures of orientalols A, B, and C, isolated from the less polar fraction of the crude drug together with two known sesquiterpenes, alismol and alismoxide. On the basis of the chemical and physicochemical evidence, the structures of orientalols A, B, and C have been determined and those of alismol and alismoxide were revised. All five sesquiterpenes were found to show an inhibitory effect on the contraction of isolated bladder smooth muscle induced by carbachol.

摘要

在对中国泽泻的三萜类成分进行表征之后，我们研究了从该生药的低极性部分分离得到的东方醇A、B和C的化学结构，同时还研究了两种已知的倍半萜类化合物泽泻醇和泽泻醇氧化物。基于化学和物理化学证据，确定了东方醇A、B和C的结构，并对泽泻醇和泽泻醇氧化物的结构进行了修正。发现所有这五种倍半萜类化合物对卡巴胆碱诱导的离体膀胱平滑肌收缩均有抑制作用。