Yoshikawa M, Yamaguchi S, Matsuda H, Tanaka N, Yamahara J, Murakami N
Kyoto Pharmaceutical University, Japan.
Chem Pharm Bull (Tokyo). 1994 Dec;42(12):2430-5. doi: 10.1248/cpb.42.2430.
From the water-soluble portion of Chinese Alismatis Rhizoma, four bioactive sesquiterpenes, sulfoorientalols a, b, c, and d, were isolated and their structures having a sulfonic acid function were established on the basis of chemical and physicochemical evidence. In addition, two sulfoorientalol congeners were derived from alismol by sulfonation of the exo-methylene moiety. Sulfoorientalols and the synthetic congeners were found to inhibit the carbachol-induced contraction of isolated bladder smooth muscle of guinea pig.
从泽泻的水溶性部分分离出四种具有生物活性的倍半萜，即磺基泽泻醇a、b、c和d，并根据化学和物理化学证据确定了它们具有磺酸官能团的结构。此外，通过对外亚甲基部分进行磺化反应，从泽泻醇衍生出两种磺基泽泻醇同系物。研究发现，磺基泽泻醇及其合成同系物能够抑制卡巴胆碱诱导的豚鼠离体膀胱平滑肌收缩。
